Linearized esculentin 2 EM (E2EM-lin) from the frog, Glandirana emeljanovi was highly active against Gram-positive bacteria (minimum lethal concentration ≤ 5.0 μM) and strongly α-helical… Continue reading Biophysical studies on the antimicrobial activity of linearized esculentin 2EM
Leah Pandiscia, PhD
March 24, 2020
Graphene-based biosensors have attracted considerable attention due to their advantages of label-free detection and high sensitivity. Many such biosensors utilize… Continue reading Control of Protein Conformation and Orientation on Graphene
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As… Continue reading Epigenetic modification of cytosines fine tunes the stability of i-motif DNA
Leah Pandiscia, PhD
March 24, 2020
KTM is a 16 amino acid peptide with the sequence WCCSYPGCYWSSSKWC. Here, we present the nuclear magnetic resonance (NMR) structure… Continue reading Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
Leah Pandiscia, PhD
March 24, 2020
Nanodiscs (NDs) are an excellent alternative to small unilamellar vesicles (SUVs) for studies of membrane protein structure, but it has… Continue reading Folding of the β-Barrel Membrane Protein OmpA into Nanodiscs
Leah Pandiscia, PhD
March 24, 2020
A poly[(methyl methacrylate/2,2,2-trifluoroethyl methacrylate/benzyl methacrylate) = 52/42/6 (w/w/w)] copolymer was used to form the core of a polymer optical fiber (POF) with… Continue reading Stress-induced absorption of a birefringence-reduced polymer optical fiber with doped core
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Insulin-like peptide 5 (INSL5) is a very important pharma target for treating human conditions such as anorexia and diabetes. However,… Continue reading Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Regulation of protein’s charge state in electrospray is of great importance to the analysis of proteins. Different methods have been… Continue reading Strong Acid Anions Significantly Increasing the Charge State of Proteins during Electrospray Ionization
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
A new tailor-made colorimetric chemosensor, (E)-1-(benzo[d]thiazol-2-yl)-3-(pyridin-3-yldiazenyl)naphthalen-2-ol (1), containing benzothiazole and pyridine moieties connected through an azo (-N=N-) linkage has been… Continue reading Multianalyte azo dye as an on-site assay kit for colorimetric detection of Hg2+ions and electrochemical sensing of Zn2+ ions
Leah Pandiscia, PhD
March 24, 2020
Isomerization of aspartate to isoaspartate (isoAsp) on aging causes protein damage and malfunction. Protein-L-isoaspartyl methyltransferase (PIMT) performs a neuroprotective role… Continue reading The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase
Leah Pandiscia, PhD
March 24, 2020
Cells are crowded with various cosolutes including salts, osmolytes, nucleic acids, peptides and proteins. These cosolutes modulate the protein folding… Continue reading Thermal stability modulation of the native and chemically-unfolded state of bovine serum albumin by amino acids
Leah Pandiscia, PhD
March 24, 2020
It is now accepted that reactive oxygen species (ROS) are not only dangerous oxidative agents but also chemical mediators of… Continue reading On the mechanism of calcium‐dependent activation of NADPH oxidase 5 (NOX5)
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Herbicidal activity-guided isolation from the fermentation extract of Penicillium viridicatum had obtained two herbicidal series of polyketides (1–7) and diketopiperazine derivatives (8–11),… Continue reading Herbicidal Polyketides and Diketopiperazine Derivatives from Penicillium viridicatum
Leah Pandiscia, PhD
June 29, 2020
Forming of neurotoxic aggregates of a small neuronal protein – alpha-synuclein (ASN) – is considered one of the main reasons of… Continue reading Inhibitory effect of Euphorbia tannins on α-synuclein aggregation in aqueous solutions
Leah Pandiscia, PhD
March 24, 2020
Lysozyme (Ly) is a good natural food preservative. However, its enzyme activity is easily influenced by food components, such as… Continue reading Effect of tannic acid on lysozyme activity through intermolecular noncovalent binding
Leah Pandiscia, PhD
March 24, 2020