Leah Pandiscia, PhD
November 2, 2018
Water speciation in the sodium disilicate melts containing 1.3–8.1 wt.% of total water was studied by near-infrared spectroscopy at 900 °C and… Continue reading In situ spectroscopic study of water speciation in the depolymerized Na2Si2O5 melt
Leah Pandiscia, PhD
November 2, 2018
The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and… Continue reading Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs
Leah Pandiscia, PhD
November 2, 2018
The titanium dioxide (TiO2)-based layers sensitized with carmine and morin dyes were prepared using commercial P25 TiO2 powder as starting material.… Continue reading Physical–chemical characterization of titanium dioxide layers sensitized with the natural dyes carmine and morin
Leah Pandiscia, PhD
November 2, 2018
Molar absorptivity of the infrared (IR) fundamental OH-stretching vibration band at 3550 cm−1 was determined for rhyolitic glasses. Five obsidian samples,… Continue reading Determination of molar absorptivity of IR fundamental OH-stretching vibration in rhyolitic glasses
Leah Pandiscia, PhD
November 2, 2018
A novel bowl-type triarylgermyl group, tris(2,2″,6,6″-tetramethyl[1,1′:3′,1″-terphenyl]-5′-yl)germyl (denoted as TRMG), was designed, and a germanol and its derivatives bearing this framework… Continue reading Syntheses and Structural Characterizations of a Novel Bowl-Type Germanol and Its Derivatives
Leah Pandiscia, PhD
November 2, 2018
The dehydration rate of hydrous rhyolitic glasses at 475–875 °C was measured by in situ infrared (IR) spectroscopy in order… Continue reading Water diffusivity in rhyolitic glasses as determined by in situ IR spectroscopy
Leah Pandiscia, PhD
November 2, 2018
We have previously reported a novel method for measuring the spectral properties and orientation of fluorescent probes in solution, which… Continue reading Fluorescence detected linear dichroism of small molecules oriented on polyethylene film
Leah Pandiscia, PhD
October 29, 2018
Miniproteins are lying between larger biologics and small molecules in size, and presumably possess the advantages of both, which represent… Continue reading CXC-Mediated Cellular Uptake of Miniproteins: Forsaking “Arginine Magic”
Leah Pandiscia, PhD
October 11, 2018
The study investigates the role of the electrostatic interactions in the fibrillation of the hen egg white lysozyme (HEWL). In order to achieve this… Continue reading Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Cupredoxins are copper-dependent electron-transfer proteins that can be categorized as blue, purple, green, and red depending on the spectroscopic properties… Continue reading Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein
Leah Pandiscia, PhD
October 11, 2018
Eukaryotic lysyl-tRNA synthetases (LysRS) have an N-terminal appended tRNA-interaction domain (RID) that is absent in their prokaryotic counterparts. This domain… Continue reading Nucleic Acid-Dependent Structural Transition of the Intrinsically Disordered N-Terminal Appended Domain of Human Lysyl-tRNA Synthetase
Leah Pandiscia, PhD
October 11, 2018
Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are secreted by Gram-negative bacteria and function as primary virulence-promoting macromolecules that deliver multiple cytopathic… Continue reading Structural basis of inactivation of Ras and Rap1 small GTPases by Ras/Rap1-specific endopeptidase from the sepsis-causing pathogen Vibrio vulnificus
Leah Pandiscia, PhD
October 11, 2018
Apolipoprotein A‐I (ApoA‐I) related amyloidosis is a rare disease caused by missense mutations in the APOA1 gene. These mutations lead to protein… Continue reading High‐efficient bacterial production of human ApoA‐I amyloidogenic variants
Leah Pandiscia, PhD
October 11, 2018
DNA can form diverse structures, which predefine their physiological functions. Besides duplexes that carry the genetic information, quadruplexes are the… Continue reading High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads
Leah Pandiscia, PhD
October 11, 2018
Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from… Continue reading Antibacterial and Antibiofilm Activity and Mode of Action of Magainin 2 against Drug-Resistant Acinetobacter baumannii
Leah Pandiscia, PhD
October 11, 2018
Thermally-responsive, short elastin-like peptides (ELPs) of sequence VPGVG (V, P and G represent valine, proline and glycine respectively), bearing different… Continue reading Short elastin-like peptide-functionalized gold nanoparticles that are temperature responsive under near-physiological conditions
Leah Pandiscia, PhD
October 11, 2018
Engineered odorant-binding proteins (OBPs) display tunable binding affinities triggered by temperature alterations. We designed and produced two engineered proteins based… Continue reading Two Engineered OBPs with opposite temperature-dependent affinities towards 1-aminoanthracene
Leah Pandiscia, PhD
October 11, 2018
NMR-guided isolation (based on 1D 1H and 13C NMR resonances consistent with a chlorovinylidene moiety) resulted in the characterization of… Continue reading Trichophycins B-F, chlorovinylidene-containing polyketides isolated from a cyanobacterial bloom.
Leah Pandiscia, PhD
October 11, 2018