Spatiotemporal control over the regulation of intra‐ and intermolecular motions in naturally occurring systems is systematically studied to expand the… Continue reading Reversible Photocontrol of DNA Melting by Visible‐Light‐Responsive F4‐Coordinated Azobenzene Compounds
Leah Pandiscia, PhD
October 11, 2018
Single amino acid mutations in profilin 1 (PFN1) have been found to cause amyotrophic lateral sclerosis (ALS). Recently, we developed… Continue reading Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Incorporating charged amino-acid side chains in polypeptides polymer backbone to improve solubility, usually leads to reduced secondary structuring. Here we… Continue reading IONIC POLYPEPTIDE POLYMERS WITH UNUSUAL β-SHEET STABILITY
Leah Pandiscia, PhD
October 11, 2018
The differential transcriptional expression of CLIC4 between tumor cells and the surrounding stroma during cancer progression has been suggested to have a… Continue reading A G-Quadruplex Structure in the Promoter Region of CLIC4 Functions as a Regulatory Element for Gene Expression
Leah Pandiscia, PhD
October 11, 2018
Cotranslational folding (CTF) is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the formation of misfolded states.… Continue reading Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
The reaction of the antimetastatic ruthenium(III) drug NAMI A with human H-chain ferritin (HuHf) was investigated through a variety of… Continue reading The NAMI A – human ferritin system: a biophysical characterization
Leah Pandiscia, PhD
October 11, 2018
Fabry disease (FD) is an X-linked lysosomal storage disease. It is caused by deficiency of the enzyme α-galactosidase A (α-Gal A), which leads to excessive… Continue reading Non-clinical evaluation of JR-051 as a biosimilar to agalsidase beta for the treatment of Fabry disease
Leah Pandiscia, PhD
October 11, 2018
An organocatalytic enantioselective Mannich reaction between rhodanines and isatin-derived ketimines was developed. With 2 mol% of a quinine-based tertiary amine-thiourea… Continue reading Enantioselective Mannich reaction between rhodanines and isatin-derived ketimines to construct vicinal tetrasubstituted stereocenters
Leah Pandiscia, PhD
October 11, 2018
The synthesis of ABA and ABA′ triblock polyethylene glycol‐and polysarcosine‐peptide conjugates is reported. The A/A′ peptides are based on phenylalanine(F)‐histidine(H)… Continue reading Secondary Structure‐Driven Hydrogelation Using Foldable Telechelic Polymer–Peptide Conjugates
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Herein, we have investigated the effect of cationic gemini surfactant (hexanediyl-α,ω-bis-(N-(2-hydroxyethyl)N-methylhexadecylammonium bromide), (16-6-16MEA) and its monomeric counterpart (N-(2-hyroxyethyl)N, N-dimethylhexadecylammonium bromide), (16MEA) on… Continue reading Comparative effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability of phospholipase A2
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Thioquinomycins A-D (1–4), four novel naphthothiophenediones were isolated from the rice-based medium of the marine-derived Streptomyces sp. SS17F. Their structures were elucidated… Continue reading Thioquinomycins A-D, novel naphthothiophenediones from the marine-derived Streptomyces sp. SS17F
Leah Pandiscia, PhD
October 11, 2018
New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307.… Continue reading Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307
Leah Pandiscia, PhD
October 11, 2018
Lactobacillus plantarum is one of the most predominant species in the human gut microbiota of healthy individuals. We have previously characterized… Continue reading Structural Characterization of the Lactobacillus Plantarum FlmC Protein Involved in Biofilm Formation
Leah Pandiscia, PhD
October 11, 2018
BZ junctions, which connect B-DNA to Z-DNA, are necessary for local transformation of B-DNA to ZDNA in the genome. However,… Continue reading Sequence preference and structural heterogeneity of BZ junctions
Leah Pandiscia, PhD
October 11, 2018
A theoretical and experimental characterization of N(1)‐(2′,3′‐dihydroxypropil)thymine (DHPT), a potential prebiotic nucleoside analogue of 5‐methyluridine, is performed. A proposed methodology… Continue reading Theoretical and experimental evidence of conformational transformation in stereoisomers of nucleoside analogues
Leah Pandiscia, PhD
October 11, 2018