The ability of peptides to self-assemble represents a valuable tool for the development of biomaterials of biotechnological and/or biomedical interest.… Continue reading Assembly modes of hexaphenylalanine variants as function of the charge states of their terminal ends.
Leah Pandiscia, PhD
October 11, 2018
Four new glyco-conjugated tacrine derivatives, 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (1), 4-(2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (2), 2′-(1,2,3,4-tetrahydroacridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-1′,3′-thiazolidin-4′-one (3) and [2′-(1,2,3,4-tetrahydro-acridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4′-oxothiazolidin-5-yliden]acetate (4) were synthesized and their characteristics were… Continue reading Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y
Leah Pandiscia, PhD
October 11, 2018
Prothymosin-α is a small, multifunctional intrinsically disordered protein associated with cell survival and proliferation which binds multiple Zn2+ ions and undergoes… Continue reading Zn2+‑binding in the glutamate‑rich region of the intrinsically disordered protein prothymosin‑alpha
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
In recent years, air pollution has been a subject of great scientific and public interests for the strong impact on… Continue reading The porcine odorant-binding protein as molecular probe for benzene detection
Leah Pandiscia, PhD
October 11, 2018
Rapid and accurate determination of H2O2 is of great importance in practical applications. In this study, we demonstrate construction of… Continue reading Fabrication of liquid crystal-based optical sensing platform for detection of hydrogen peroxide and blood glucose
Leah Pandiscia, PhD
October 11, 2018
The 2′‐O,4′‐C‐methylene‐bridged nucleic acid (2′,4′‐BNA/LNA), having an N‐type sugar conformation, effectively improves duplex‐forming ability. 2′,4′‐BNA/LNA is widely used to improve… Continue reading 2′‐O,4′‐C‐Methylene‐bridged nucleic acids stabilize metal‐mediated base pairing in a DNA duplex
Leah Pandiscia, PhD
October 11, 2018
Two pairs of chiral cyano-bridged heterobimetallic compounds, [Mn(salen)Ru((R,R)-(5-Br-salcy))(CN)2]n (1), [Mn(salen)Ru((S,S)-(5-Br-salcy))(CN)2]n (2), [Ni(tren)][Ru((R,R)-(5-Cl-salcy))(CN)2]2 (3), and [Ni(tren)][Ru((S,S)-(5-Cl-salcy))(CN)2]2 (4) [salcy2− = N,N’-(1,2-cyclohexanediylethylene) bis(salicylideneiminato)… Continue reading Synthesis, structures and magnetic properties of heterbimetallic RuIII-3d (3d = Mn, Ni) compounds based on the chiral RuIII building block
Leah Pandiscia, PhD
October 11, 2018
Which conformational parameters lead to an antibody-affine peptide antigen? And in how many different conformations can we actually present the… Continue reading A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Amyloids adopt ‘cross-β’ structures composed of long, twisted fibrils with β-strands running perpendicular to the fibril axis. Recently, a toxic… Continue reading Designed peptides that assemble into cross-α amyloid-like structures
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Carboligations catalyzed by aldolases or thiamine diphosphate (ThDP)-dependent enzymes are well-known in biocatalysis to deliver enantioselective chain elongation reactions. A… Continue reading Extended substrate range of thiamine diphosphate-dependent MenD enzyme by coupling of two C–C-bonding reactions
Leah Pandiscia, PhD
October 11, 2018
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that play a central role in neuronal and neuromuscular signal transduction.… Continue reading α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor
Leah Pandiscia, PhD
October 11, 2018
Despite the importance of membrane proteins in cellular processes, studies of these hydrophobic proteins present major technical challenges, including expression… Continue reading Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions
Leah Pandiscia, PhD
October 11, 2018
Protein materials are rapidly gaining interest in materials sciences and nanomedicine because of their intrinsic biocompatibility and full biodegradability. The… Continue reading Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles
Leah Pandiscia, PhD
October 11, 2018
Three new blennolide derivatives, blennolides L-N (1–3), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were… Continue reading Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Three new indolocarbazoles alkaloids together with nine known compounds were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. A65. Their structures… Continue reading Cytotoxic indolocarbazoles alkaloids from the streptomycessp. A65
Leah Pandiscia, PhD
October 11, 2018