Cationic liposomes give rise to stable complexes with DNA molecules (lipoplexes) that are of great interest for gene delivery applications.… Continue reading DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques
Leah Pandiscia, PhD
July 28, 2017
Human α1-acid glycoprotein (AGP) is an important drug binding plasma protein which affects pharmacokinetical properties of various therapeutic agents. For… Continue reading The drug binding site of human α1-acid glycoprotein: Insight from induced circular dichroism and electronic absorption spectra
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The non-covalent interactions of (dG-dC)10 and (dA-dT)10 with 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) were studied using the combination of electronic circular dichroism (ECD), vibrational circular… Continue reading Electronic and vibrational circular dichroism spectroscopic study of non-covalent interactions of meso-5,10,15,20-tetrakis (1-methylpyridinium-4-yl)porphyrin with (dG-dC)10 and (dA-dT)10
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Hemoproteins have been recognized for nearly a century and are ubiquitous components of cellular organisms. Despite our familiarity with these… Continue reading Magnetic circular dichroism of hemoproteins with in situ control of electrochemical potential: “MOTTLE”
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The binding to human serum albumin (HSA) of the antitumoural drug paclitaxel and of several structural analogues has been characterized… Continue reading Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroism
Leah Pandiscia, PhD
July 28, 2017
Proinsulin C-peptide has been recently described as an endogenous peptide hormone, responsible for important physiological functions others than its role… Continue reading Molecular dynamics and circular dichroism studies of human and rat C-peptides
Leah Pandiscia, PhD
July 28, 2017
The HPLC enantiomeric separation of the racemic cularinoid alkaloids N-p-methoxy-1,α-dihydroaristoyagonine (1) and 4′,5′-demethoxy-1,α-dihydroaristoyagonine (2) was accomplished using five chiral stationary phases… Continue reading Chiral high-performance liquid chromatographic separation and circular dichroism spectra of the enantiomers of cytotoxic aristocularine alkaloids
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The polyanionic glycosaminoglycans (GAGs) are intimately involved in the pathogenesis of protein conformational disorders such as amyloidosis and prion diseases.… Continue reading Binding of anti-prion agents to glycosaminoglycans: Evidence from electronic absorption and circular dichroism spectroscopy
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
DNA can adopt structures in solution apart from the well-known Watson–Crick double helix, ranging from disordered single strands to high-order… Continue reading Classification of nucleic acids structures by means of the chemometric analysis of circular dichroism spectra
Leah Pandiscia, PhD
July 28, 2017
Solutions of meso-tetrakis [3-methoxy-4-(N-carbazyl)n-hexyloxyphenyl] porphyrin (4C6-TPP) in a water–organic mixture (tetrahydrofuran, THF) generate aggregates with absorption spectra characterized by broader… Continue reading Solvent effects on the absorption, circular dichroism and Raman spectroscopy of meso-tetrakis [3-methoxy-4-(N-carbazyl)n-hexyloxyphenyl] porphyrin in water–THF solution
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017