Found 9617 Results / Page 56 of 481
2021 / Scientific reports
Adjuvant-aided combination chemotherapy is one of the most effective ways of cancer treatment by overcoming the multidrug resistance (MDR) and… Continue reading Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells
2021 / Communications Biology
Circular tandem repeat proteins (‘cTRPs’) are de novo designed protein scaffolds (in this and prior studies, based on antiparallel two-helix… Continue reading Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces
2021 / Nature Communications
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated… Continue reading A protein tertiary structure mimetic modulator of the Hippo signalling pathway
2021 / biomolecules
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved… Continue reading Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins
2021 / Journal of Fungi
Monascus species are asexually or sexually reproduced homothallic fungi that can produce a red colorant, specifically the so-called red yeast… Continue reading Investigations into Chemical Components from Monascus purpureus with Photoprotective and Anti-Melanogenic Activities
2021 / Desalination
Interfacial solar desalination shows great promise to become an alternative technique for freshwater generation. However, the unavoidable fouling undermines continuous… Continue reading Carbonized cattle manure-based photothermal evaporator with hierarchically bimodal pores for solar desalination in high-salinity brines
2021 / Chromatography Today
Cannabinoid is a generic term for the chemical substances contained in cannabis plants. Tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD)… Continue reading Analysis of Cannabidiol in CBD products by SFC-CD-MS
2021 / Biophysical Journal
Understanding the structure of messenger RNA (mRNA) lipid nanoparticles, and specifically the microenvironment of the mRNA molecules within these entities,… Continue reading Encapsulation state of messenger RNA inside lipid nanoparticles
2021 / Nature Communications
The acidic tumor microenvironment in melanoma drives immune evasion by up-regulating cyclic adenosine monophosphate (cAMP) in tumor-infiltrating monocytes. Here we… Continue reading Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
2021 / Nature Communications
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is… Continue reading Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
2021 / Nature Communications
Molecular engineering via functionalization has been a great tool to tune noncovalent intermolecular interactions. Herein, we demonstrate three-dimensional highly crystalline… Continue reading Enabling three-dimensional porous architectures via carbonyl functionalization and molecular-specific organic-SERS platforms
2021 / Nature Communications
Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for… Continue reading Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota
2021 / Nature Communications
Marine debris, which is often called microplastics, is widespread in marine environments, particularly in sediments, and is recognized as an… Continue reading Proposal for an initial screening method for identifying microplastics in marine sediments
2021 / Scientific reports
5-Amino-8-hydroxyquinoline (5A8HQ), an amino derivative of 8-hydroxyquinoline, has become a potential anticancer candidate because of its promising proteasome inhibitory activity… Continue reading In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent
2021 / Scientific reports
Due to unique optical/mechanical properties and significant resistance to harsh radiation environments, corundum (α-Al2O3) is considered as a promising candidate… Continue reading Evidence for the formation of two types of oxygen interstitials in neutron-irradiated α-Al2O3 single crystals
2021 / Scientific reports
The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies… Continue reading Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies
2021 / Communiation Biolory
Color tuning in animal and microbial rhodopsins has attracted the interest of many researchers, as the color of their common… Continue reading Pro219 is an electrostatic color determinant in the light-driven sodium pump KR2
2021 / Nature Communications
Photophysical and photochemical properties of graphene quantum dots (GQDs) strongly depend on their morphological and chemical features. However, systematic and… Continue reading Structure-controllable growth of nitrogenated graphene quantum dots via solvent catalysis for selective C-N bond activation
2021 / Nature Communications
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA… Continue reading Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia
2021 / Nature Communications
In spite of their great importance in biology, methods providing access to spontaneous molecular interactions with and on biological membranes… Continue reading Mass-sensitive particle tracking to elucidate the membrane-associated MinDE reaction cycle
