Substitution of PPh3+ as a lipophilic cation on new water-soluble Co(II) and Zn(II) Schiff base complexes: effect of central metal and substitutional group of ligand on DNA-complex interaction

2017 / Journal of Photochemistry and Photobiology A: Chemistry

New series of water soluble Schiff base complexes by conjugating the lipophilic triphenylphosphonium cation to aromatic moiety of Schiff base …

Leah Pandiscia, PhD

Study on effect of lomefloxacin on human holo-transferrin in the presence of essential and nonessential amino acids: Spectroscopic and molecular modeling approaches

2017 / International Journal of Biological Macromolecules

The purpose of this study was to determine how lomefloxacin (LMF) interacts with human holo-transferrin (HTF) in the presence of …

Leah Pandiscia, PhD

Label free checkerboard assay to determine overlapping epitopes of Ebola virus VP-40 antibodies using surface plasmon resonance

2017 / Journal of Immunological Methods

Immunoassay formats, in which antibodies provide sensitivity and specificity, are often utilized to provide rapid and simple diagnostic tests. Surface …

Leah Pandiscia, PhD

Exploring the mode of binding between food additive “butylated hydroxytoluene (BHT)” and human serum albumin: Spectroscopic as well as molecular docking study

2017 / Journal of Molecular Liquids

Butylated hydroxytoluene (BHT) is a food additive and used as an antioxidant in food products. BHT also concerning several health …

Leah Pandiscia, PhD

Rv0774c, an iron stress inducible, extracellular esterase is involved in immune-suppression associated with altered cytokine and TLR2 expression

2017 / International Journal of Medical Microbiology

Tuberculosis, one of the leading cause of death from infectious diseases, is caused by Mycobacterium tuberculosis. The genome of M. tuberculosis has been …

Leah Pandiscia, PhD

Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner

2017 / Tuberculosis

Mycobacterium tuberculosis (M.tb), tuberculosis (TB) causing bacteria, employs several mechanisms to maintain iron homeostasis which is critical for its survival and …

Leah Pandiscia, PhD

Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae

2017 / Developmental & Comparative Immunology

Alligator mississippiensis (American alligator), a member of order Crocodilia, lives in bacteria-laden environments but is not often known to succumb to …

Leah Pandiscia, PhD

Two new benzoyl glucuronosyl glycerols from the leaves of Garcinia buchananii Baker

2017 / Phytochemistry Letters

Two new benzoyl glucuronosyl glycerols, (2R)-1-O-4-hydroxy-benzoyl-3-O-α-d-glucuronosyl glycerol (1) and (2S)-1-O-4-hydroxy-3-methoxy-benzoyl-3-O-α-d-glucuronosyl glycerol (2), together with helicioside (3), quercetin-6-C-β-d-glucopyranoside (4), apigenin-8-C-β-d-glucopyranosyl-2″-O-L-rhamnopyranoside (5), …

Leah Pandiscia, PhD

Exploration of a multi-target ligand, dehydroevodiamine, for the recognition of three G-quadruplexes in c-Myb proto-oncogene by ESI–MS

2017 / International Journal of Mass Spectrometry

In this research, ESI mass spectrometry was used to probe the formation of G-quadruplexes from three G-rich sequences (S1–S3) in …

Leah Pandiscia, PhD

What stoichiometries determined by mass spectrometry reveal about the ligand binding mode to G-quadruplex nucleic acids ☆

2017 / Biochimica et Biophysica Acta (BBA) - General Subjects

G-quadruplexes (G4s) have become important drug targets to regulate gene expression and telomere maintenance. Many studies on G4 ligand binding …

Leah Pandiscia, PhD