Structural Characterization of the Heterobactin Siderophores from Rhodococcus erythropolis PR4 and Elucidation of their Biosynthetic Machinery.

2013 / Journal of Natural Products

In this study, the isolation, the structural characterization, and the elucidation of the biosynthetic origin of heterobactins, catecholate-hydroxamate mixed-type siderophores …

Leah Pandiscia, PhD

Alteration in DNA binding pattern of conformationally locked NC(O)N system: A spectroscopic investigation

2016 / International Journal of Biological Macromolecules

The binding mode of a conformationally locked single bondNC(O)Nsingle bond planar system with deoxyribonucleic acid (DNA) is investigated using various spectroscopic and …

Leah Pandiscia, PhD

Functional Stability and Structural Transitions of Kallikrein: Spectroscopic and Molecular dynamics studies

2016 / Journal of Biomolecular Structure and Dynamics

Kallikrein, a physiologically vital serine protease, was investigated for its functional and conformational transitions during chemical (organic solvents, Gdn-HCl), thermal, …

Leah Pandiscia, PhD

Enantiodifferentiating [4 + 4] photocyclodimerization of 2-anthracenecarboxylate catalyzed by 6A,6X-diamino-6A,6X-dideoxy-γ-cyclodextrins: Manipulation of product chirality by electrostatic interaction, temperature and solvent in supramolecular photochirogenesis

2016 / Journal of Photochemistry and Photobiology A: Chemistry

6A,6X-Dideoxy-6A,6X-diamino-γ-cyclodextrins (X = B, C, D and E) 5a–d were synthesized as chiral hosts for catalyzing the enantiodifferentiating [4 + 4] photocyclodimerization of 2-anthracenecarboxylic acid (ACA). …

Leah Pandiscia, PhD

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

2016 / Molecular Neurodegeneration

11Lrrk2, a gene linked to Parkinson’s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle …

Leah Pandiscia, PhD

The fabrication of helical fibers with circularly polarized luminescence viaionic linkage of binaphthol and tetraphenylethylene derivatives

2016 / Journal of Materials Chemistry C

Assemblies with helical fiber nanostructures were fabricated via simple ionic linkage of a cationic tetraphenylethylene derivative (TPEHexN+) and an anionic binaphthyl derivative …

Leah Pandiscia, PhD

The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV‑1 gp41 by Displacement of the C‑Terminal Helical Repeat Region

2015 / Biochemistry

The conformational transition of the core domain of HIV-1 gp41 from a prehairpin intermediate to a six-helix bundle is responsible …

Leah Pandiscia, PhD

Probing Electronic Communications in Heterotrinuclear Fe−Ru−Fe Molecular Wires Formed by Ruthenium(II) Tetraphenylporphyrin and Isocyanoferrocene or 1,1′-Diisocyanoferrocene Ligands

2015 / Inorganic Chemistry

Two new heterotrinuclear Fe–Ru–Fe complexes of ruthenium(II) tetraphenylporphyrin axially coordinated with a pair of isocyanoferrocene ((FcNC)2RuTPP, 1) or 1,1′-diisocyanoferrocene (([C5H4NC]2Fe)2RuTPP, 2) ligands …

Leah Pandiscia, PhD

Inhibition effect of neo-lignans from Eleutherococcus senticosus (Rupt. & Maxim.) Maxim on diacylglycerol acyltransferase (DGAT)

2016 / Phytochemistry Letters

Two new neo-lignans, erythro-7E-4′,9′-dihydroxy-4,5′-dimethoxy-5,8′-oxyneolign-7-en-9-al (1) and 4,5′-dimethoxy-lariciresinol (2) together with five known compounds (3-7) were isolated from the EtOAc-soluble extract of Eleutherococcus …

Leah Pandiscia, PhD