Talaflavuterpenoid A (1), a new nardosinane-type sesquiterpene, was isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and its structure was elucidated… Continue reading Talaflavuterpenoid A, a new nardosinane-type sesquiterpene from Talaromyces flavus
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Three hydrogen bonded three-dimensional (3D) metal–organic frameworks (MOFs) namely [Cd(L-tart)- (bpy)(H2O)]n·9n(H2O) (1), [Cd(D-tart)(bpy)(H2O)]n·9n(H2O) (2) and [Cd(DL-tart)(bpy)(H2O)]n·6n(H2O) (3) (tart = tartaric… Continue reading Synthesis, characterisation, water adsorption and proton conductivity of three Cd(II) based luminescent metal–organic frameworks
Leah Pandiscia, PhD
July 28, 2017
Stereochemical assignment of amino acids and corresponding codons or anticodons has not been successful so far. Here, we focused on… Continue reading Proline Might Have Been the First Amino Acid in the Primitive Genetic Code
Leah Pandiscia, PhD
July 28, 2017
Conventional empirical methods for the quantification of the helical content of proteins in solution using circular dichroism (CD) primarily rely… Continue reading Protein helical structure determination using CD spectroscopy for solutions with strong background absorbance from 190 to 230 nm
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In addition to its electron transfer activity, cytochrome c is now known to trigger apoptosis via peroxidase activity. This new function is… Continue reading Versatility of non-native forms of human cytochrome c: pH and micellar concentration dependence
Leah Pandiscia, PhD
July 28, 2017
Graphene oxide is a one-atom thick layer of graphite and has evolved as a promising precursor for preparing graphene-based composite… Continue reading Formation of hemoglobin assisted graphene oxide biocomposite film
Leah Pandiscia, PhD
July 28, 2017
Very short alanine peptide helices can be studied in a fixed-nucleus, helix-forming system [Siedlicka, M., Goch, G., Ejchart, A., Sticht,… Continue reading Circular dichroism spectra of short, fixed-nucleus alanine helices
Leah Pandiscia, PhD
July 28, 2017
The far-UV circular dichroism spectra of a series of amino acid derivatives containing single peptide bonds have been measured. The N-acetyl-alanine… Continue reading Single Peptide Bonds Exhibit Poly(Pro)II (“Random Coil”) Circular Dichroism Spectra
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs) and mucins are components of airway secretions and both contribute to the innate host defense system. At neutral pH, AMPs… Continue reading The antimicrobial peptide cathelicidin interacts with airway mucus
Leah Pandiscia, PhD
July 28, 2017
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II consists of tandemly repeated copies of a heptapeptide… Continue reading Conformation of the RNA Polymerase II C-Terminal Domain: Circular Dichroism of Long and Short Fragments
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Addition of 8-anilino-1-naphthalenesulfonate (ANS) to acid-denatured pectate lyase C (pelC) leads to a large increase in the fluorescence quantum yield… Continue reading A partially folded intermediate conformation is induced in pectate lyase C by the addition of 8-anilino-1-naphthalenesulfonate (ANS)
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The left-handed polyproline II (PPII) helix gives rise to a circular dichroism spectrum that is remarkably similar to that of… Continue reading Polyproline II helical structure in protein unfolded states: Lysine peptides revisited
Leah Pandiscia, PhD
July 28, 2017
(−)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of… Continue reading New Spiral γ-Lactone Enantiomers from the Plant Endophytic FungusPestalotiopsis foedan
Leah Pandiscia, PhD
July 28, 2017
To investigate the protective effects of curcumin against amyloid-b (Ab)-induced neuronal damage. Primary rat cortical neurons were cultured with different… Continue reading Protective Effects of Curcumin on Amyloid-β-Induced Neuronal Oxidative Damage
Leah Pandiscia, PhD
July 28, 2017
The leukemia-associated fusion protein RUNX1/ETO is generated by the chromosomal translocation t(8;21) which appears in about 12% of all de novo acute… Continue reading Interference with RUNX1/ETO Leukemogenic Function by Cell-Penetrating Peptides Targeting the NHR2 Oligomerization Domain
Leah Pandiscia, PhD
July 28, 2017