2016 / A European Journal of Chemical Biology
G-quadruplex (G4) DNA is often observed as a DNA secondary structure in guanine-rich sequences and is thought to be relevant… Continue reading Ligand-mediated G-quadruplex Induction in a Double-stranded DNA Context by Cyclic Imidazole/Lysine Polyamide
2016 / Microporous and Mesoporous Materials
Aiming to broaden our understanding on the interplay of silica nanomaterials with living biocells, we designed herein various surface-functionalized mesoporous… Continue reading Impact of mesoporous silica surface functionalization on human serum albumin interaction, cytotoxicity and antibacterial activity
2016 / A European Journal of Chemical Biology
Understanding and controlling the molecular interactions between enzyme substrates and DNA nanostructures has important implications in the advancement of enzyme-DNA… Continue reading Mechanisms of enhanced catalysis in enzyme-DNA nanostructures revealed through molecular simulations and experimental analysis
2016 / Chirality
Circular dichroism (CD) calculations of flexible natural products have been difficult because of the large number of low-energy conformers and… Continue reading Reducing Molecular Flexibility by Cyclization for Elucidation of Absolute Configuration by CD Calculations: Daurichromenic Acid
2016 / Molecular Microbiology
The bacterial flagellar type III export chaperones not only act as bodyguards to protect their cognate substrates from aggregation and… Continue reading Rearrangements of α-helical structures of FlgN chaperone control the binding affinity for its cognate substrates during flagellar type III export
2016 / Journal of Inorganic Biochemistry
Herein we report investigation of the interactions between anticancer organoruthenium complexes, [(η6-arene)Ru(en)(Cl)]PF6 (en = ethylenediamine, arene = p-cymene (1) or biphenyl (2)), and the human… Continue reading A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry
2016 / Journal of Inorganic Biochemistry
Novel nickel(II) (1) and zinc(II) (2) complexes of a Salen-like ligand, carrying a pyrimidine ring on the N,N’ bridge, were… Continue reading G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes
2016 / Process Biochemistry
Surfactant ̶ protein/enzyme interactions have gained widespread interest in modern research due to their implications in various domains like pharmaceuticals,… Continue reading Biophysical analysis of a novel oxy-diester hybrid cationic gemini surfactants (Cm-E2O-Cm) with xanthine oxidase (XO)
2016 / International Journal of Biological Macromolecules
Functional and conformational transitions of the Sophora japonica seed lectin (SJL) were studied in detail using bioinformatics and biophysical tools.… Continue reading Structural–functional insights and studies on saccharide binding of Sophora japonica seed lectin
2016 / Journal of Photochemistry and Photobiology B: Biology
Exogenous ligand binding can be adequate to alter the secondary structure of biomolecules besides other external stimuli. In such cases,… Continue reading Exploration of Electrostatic Interaction in the Hydrophobic Pocket of Lysozyme: Importance of Ligand-Induced Perturbation of the Secondary Structure on the Mode of Binding of Exogenous Ligand and Possible Consequences
2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
The binding interaction of a synthesized Schiff base Fe(II) complex with biological macromolecules viz., bovine serum albumin (BSA) and calf… Continue reading Binding affinities of Schiff base Fe(II) complex with BSA and calf-thymus DNA: Spectroscopic investigations and molecular docking analysis
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Many proteins contain intrinsically disordered regions (IDRs) lacking stable secondary and ordered tertiary structure. IDRs are often implicated in macromolecular… Continue reading Identifying Intrinsically Disordered Protein Regions Likely to Undergo Binding-Induced Helical Transitions
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
In humans, glyoxylate is an intermediary product of metabolism, whose concentration is finely balanced. Mutations in peroxisomal alanine:glyoxylate aminotransferase (hAGT1)… Continue reading Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism
2016 / Chemico-Biological Interactions
As the nanoparticles (NPs) enter into the biological interface, they have to encounter immediate and first exposure to many proteins… Continue reading Bovine serum albumin interacts with silver nanoparticles with a “side-on” or “end on” conformation
2016 / International Journal of Biological Macromolecules
Termitomyces clypeatus is an edible mushroom, prized for its therapeutic values and as producer of 34 industrially important enzymes. However,… Continue reading AkP from mushroom Termitomyces clypeatus is a proteoglycan specific protease with apoptotic effect on HepG2
2016 / International Journal of Biological Macromolecules
Epoxide hydrolases (EHs) are enzymes that are present in all living organisms and catalyze the hydrolysis of epoxides to the… Continue reading Epoxide hydrolase of Trichoderma reesei: biochemical properties and conformational characterization
2016 / Catalysts
d-amino acid oxidase (DAAO) and catalase (CAT) have been genetically modified by fusing them to an elastin-like polypeptide (ELP). ELP-DAAO… Continue reading Immobilization of Genetically-Modified d-Amino Acid Oxidase and Catalase on Carbon Nanotubes to Improve the Catalytic Efficiency
2016 / Materials Science and Engineering: C
In present investigation, recombinant human insulin loaded proliposomes and protamine sulphate coated proliposomes (rh insulin-proliposomes and Pt-rh insulin proliposomes) were… Continue reading Protamine coated proliposomes of recombinant human insulin encased in Eudragit S100 coated capsule offered improved peptide delivery and permeation across Caco-2 cells
2016 / Materials Research Express
The present work is a study on the biological synthesis of cadmium sulphide (CdS) nanoparticles using blue-green algae that is… Continue reading Algae mediated synthesis of cadmium sulphide nanoparticles and their application in bioremediation
2016 / Electrochimica Acta
Electrochemical studies are reported on a series of peptides to determine the influence of different side-chains and backbone rigidity on… Continue reading Turning electron transfer ‘on-off’ in peptides through side-bridge gating
