Porphyrins are considered to be important scaffolds bridging supramolecular chemistry and chiral chemistry, where chirality selection via physical effects such as directional… Continue reading Interfacial Organization of Achiral Porphyrins via a Unidirectional Compression: a General Method for Chiroptical Porphyrin Assemblies of Selected Chirality
Leah Pandiscia, PhD
July 28, 2017
Graphitic carbon nitride (g-C3N4) has a suppressive capability toward Alzheimer’s Aβ aggregation under light-illumination. Photoinduced electrons of g-C3N4 generate reactive oxygen resulting… Continue reading Photoactive g-C3N4 Nanosheets for Light-Induced Suppression of Alzheimer’s β-Amyloid Aggregation and Toxicity
Leah Pandiscia, PhD
July 28, 2017
In this study, we examined the regio-, diastereo-, and enantioselective polymerization using asymmetric allylic alkylation catalyzed by a planar-chiral cyclopentadienyl-ruthenium… Continue reading Enantio- and diastereoselective polymerization: asymmetric allylic alkylation catalyzed by a planar-chiral Cp′Ru complex
Leah Pandiscia, PhD
July 28, 2017
Sodium octanoate and N-acetyl-L-tryptophan (N-AcTrp) are widely used as stabilizers during pasteurization and storage of albumin products. However, as compared… Continue reading N-acetyl-l-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-l-tryptophan
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Bone defects are very common in orthopedics, and there is great need to develop suitable bone grafts for transplantation in… Continue reading Functionalized d-form self-assembling peptide hydrogels for bone regeneration
Leah Pandiscia, PhD
July 28, 2017
The RNA World hypothesis presupposes that abiotic reactions originally produced nucleotides, the monomers of RNA and universal constituents of metabolism.… Continue reading Spontaneous formation and base pairing of plausible prebiotic nucleotides in water
Leah Pandiscia, PhD
July 28, 2017
The subunits that comprise bacterial complex I (NADH:ubiquinone oxidoreductase) are also found in more complicated mitochondrial enzymes in eukaryotic organisms.… Continue reading Characterization of the Nqo5 subunit of bacterial complex I in the isolated state
Leah Pandiscia, PhD
July 28, 2017
Researchers are endeavoring to find out new therapeutics for curing cancer and G-quadruplex DNA has already been identified as a… Continue reading Interaction of KRAS G-quadruplex with natural polyphenols: A spectroscopic analysis with molecular modeling
Leah Pandiscia, PhD
July 28, 2017
A series of novel hydrazino-based peptidomimetics and analogues comprising N-terminal lysine and C-terminal phenanthridinyl-L-alanine were prepared. The presented results demonstrate… Continue reading Impact of α-hydrazino acids embedded in short fluorescent peptides on peptide interaction with DNA and RNA
Leah Pandiscia, PhD
July 28, 2017
The purpose of the present study was to investigate the DNA-binding properties of mononuclear ruthenium(II) complex [Ru(tBu2bpy)2(dpp)]2+ and heterodinuclear ruthenium(II)–platinum(II) complexes… Continue reading Anticancer activity of heterodinuclear ruthenium(II)–platinum(II) complexes as photochemotherapeutic agents
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Effects of oligotryptophan end-tagging on the uptake of arginine-rich peptides into melanoma cells was investigated under various conditions and compared… Continue reading Pronounced peptide selectivity for melanoma through tryptophan end-tagging
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Synergistic therapy involving two or more therapeutic agents with different anticancer mechanisms represents a promising approach to eradicate chemotherapy-refractory cancers.… Continue reading Functional mesoporous silica nanoparticles (MSNs) for highly controllable drug release and synergistic therapy
Leah Pandiscia, PhD
July 28, 2017
Bulky camphorsulfonic acid (CSA) was used to complex with quinine (Qu) to impose restricted intramolecular rotation (RIR) required for aggregation-induced… Continue reading Multiple-responsive ionic complex luminogen of quinine and camphorsulfonic acid with aggregation-induced emission
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Nonionic surfactant, tetraethylene glycol monododecyl ether (C12EO4), cannot compact DNA because of its low efficiency in neutralizing the negative charges… Continue reading Compaction of DNA using C12EO4 cooperated with Fe3+
Leah Pandiscia, PhD
July 28, 2017
Biofunctionalization of noble metal nanoparticles (such as Ag) is necessary to obtain biocompatibility for specific biomedical applications. Silver nanoprisms (AgNPrs)… Continue reading Synthesis of triangular silver nanoprisms and studies on the interactions with human serum albumin
Leah Pandiscia, PhD
July 28, 2017
Amyloidoses are clinical disorders where deposition of β-sheet rich, misfolded protein aggregates called amyloid occurs in vital organs like brain,… Continue reading Familial mutations in fibrinogen Aα (FGA) chain identified in renal amyloidosis increase in vitro amyloidogenicity of FGA fragment
Leah Pandiscia, PhD
July 28, 2017