2016 / International Journal of Biological Macromolecules
This work aims to improve thermostability of amylomaltase from a mesophilicCorynebacterium glutamicum (CgAM) by random and site-directed mutagenesis. From error prone… Continue reading Mutagenesis for improvement of activity and thermostability of amylomaltase from Corynebacterium glutamicum
2016 / Biochimica et Biophysica Acta-Proteins and Proteomics
For de novo design of protein–protein interactions (PPIs), information on the shape and chemical complementarity of their interfaces is generally required. Recent… Continue reading De novo design of protein–protein interactions through modification of inter-molecular helix–helix interface residues
2016 / Journal of Controlled Release
Insulin is the first line therapy in type 1 diabetes and usually patients suffer from three or more daily insulin… Continue reading Dextran-b-poly(lactide-co-glycolide) polymersome for oral delivery of insulin: In vitro and in vivo evaluation
2016 / Carbohydrate Polymers
The fusion of molecular and anatomical modalities facilitates more reliable and accurate detection in clinic. In this work, we prepared… Continue reading Gd (III) complex conjugate of low-molecular-weight chitosan as a contrast agent for magnetic resonance/fluorescence dual-modal imaging
2016 / Journal of Immunological Methods
Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely used to assess the binding of peptides to… Continue reading Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes
2016 / Bioorganic & Medicinal Chemistry
Human serum albumin (HSA) and bovine β-lactoglobulin (β-Lg) are both introduced as blood and oral carrier scaffolds with high affinity… Continue reading Interaction of prodigiosin with HSA and β-Lg: Spectroscopic and molecular docking studies
2016 / Biochemical and Biophysical Research Communications
Miz-1 is a BTB/POZ transcription factor that contains 13C2H2 Zinc Finger domains (ZF). Miz-1 transactivates and represses the transcription of… Continue reading Solution structure of the 13th C2H2 Zinc Finger of Miz-1
2016 / PLoS ONE
A practical method is described for synthesizing conjugated protein nanoparticles using thioether (thiol-maleimide) cross-linking chemistry. This method fills the need… Continue reading A Method for Producing Protein Nanoparticles with Applications in Vaccines
2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Interaction mechanism of a new hyperbranched polyurethane-based ferrocene (HPU-Fc) with cytochrome c (cyt c) and cyt c structure and conformation change induced by HPU-Fc were… Continue reading Conjugation of cytochrome c with ferrocene-terminated hyperbranched polymer and its influence on protein structure, conformation and function
2016 / Food Hydrocolloids
Chitosan coating was applied in Lactoferrin (Lf)-Glycomacropeptide (GMP) nanohydrogels by layer-by-layer coating process. A volume ratio of 10 of Lf-GMP… Continue reading Influence of chitosan coating on protein-based nanohydrogels properties and in vitro gastric digestibility
2016 / Journal of Photochemistry and Photobiology B: Biology
Copper based metal complexes have been studied extensively towards DNA interaction aspects, the possible interactions being at the major or… Continue reading Spectroscopic investigations on partial intercalative binding behaviour of terpyridine based copper(II) complexes with DNA
2016 / Organic and Biomolecular Chemistry
In our present study, four new, designated as murrayakonine A–D (1–4), along with 18 known carbazole alkaloids were isolated from… Continue reading Four new carbazole alkaloids from Murraya koenigii that display anti-inflammatory and anti-microbial activities
2016 / Biochemistry
Potential guanine (G) quadruplex-forming sequences (QFSs) found throughout the genomes and transcriptomes of organisms have emerged as biologically relevant structures.… Continue reading Homologous PNA Hybridization to Noncanonical DNA G-Quadruplexes
2016 / Bioorganic Chemistry
In this study, we report the structure-activity relationships of novel derivatives of the insect peptide alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH). The peptide structure… Continue reading Novel analogs of alloferon: Synthesis, conformational studies, pro-apoptotic and antiviral activity
2016 / PLoS ONE
Ribose-5-phosphate isomerase B from Leishmania donovani (LdRpiB) is one of the potential drug targets against visceral leishmaniasis. In the present study, we… Continue reading Mutational and Structural Analysis of Conserved Residues in Ribose-5-Phosphate Isomerase B from Leishmania donovani: Role in Substrate Recognition and Conformational Stability
2016 / Cell Biology International
Recent studies have revealed that soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins interact with each other, forming a SNARE… Continue reading Phosphorylation of syntaxin-3 at Thr 14 negatively regulates exocytosis in RBL-2H3 mast cells†
2016 / ACS Biomaterials Science and Engineering
Cell sheets are useful materials in regenerative medicine; however, the cell sheet fabrication processes developed to date are associated with… Continue reading Synthetic short oligopeptides for rapid fabrication of monolayer cell sheets
2016 / Biopolymers
Hybrid silks hold a great potential as specific biomaterials due to its controlled mechanical properties. To produce fibers with tunable… Continue reading Chimeric spider silk proteins mediated by intein result in artificial hybrid silks
2016 / Biochimica et Biophysica Acta-Proteins and Proteomics
5-Aminolevulinate synthase (ALAS), a pyridoxal 5′-phosphate (PLP)-dependent homodimeric enzyme, catalyzes the initial step of heme biosynthesis in non-plant eukaryotes. The… Continue reading Murine erythroid 5-aminolevulinate synthase: Truncation of a disordered N-terminal extension is not detrimental for catalysis
2016 / Journal of Photochemistry and Photobiology B: Biology
In this study, we have investigated the binding affinity of the newly approved tyrosine kinase inhibitor nintedanib (NIB) with human… Continue reading Interplay of multiple interaction forces: Binding of tyrosine kinase inhibitor nintedanib with human serum albumin
