Effects of single-mode microwave heating and dextran conjugation on the structure and functionality of ovalbumin–dextran conjugates

2020 / Food Research International

The proteins modified with carbohydrates through the glycation reaction are capable of changing and improving the functional properties of proteins.… Continue reading Effects of single-mode microwave heating and dextran conjugation on the structure and functionality of ovalbumin–dextran conjugates

Leah Pandiscia, PhD

Stabilization of an intermolecular RNA triplex by two novel binders Lys- and Arg-rich Ru(II) polypyridyl metallopeptides

2020 / Journal of Inorganic Biochemistry

In this work, using [Ru(bpy)2(pip)]2+ (bpy = 2,2′-bipyridine, pip = 2-phenyl-1H-imidazo[4,5-f]-[1,10]-phenanthroline) as chromophores and neutral amino acid glycine as spacers, two novel Arg- and Lys-rich… Continue reading Stabilization of an intermolecular RNA triplex by two novel binders Lys- and Arg-rich Ru(II) polypyridyl metallopeptides

Leah Pandiscia, PhD

Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA

2020 / Journal of Biological Chemistry

FimA is the main structural subunit of adhesive type 1 pili from uropathogenic Escherichia coli strains. Up to 3000 copies of FimA… Continue reading Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA

Leah Pandiscia, PhD

Enantiomerically Pure Quinoline-Based k-Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

2020 / ChemMedChem

Racemic K‐opioid receptor (KOR) agonist 2‐(3,4‐dichlorophenyl)‐1‐[(4aRS ,8SR ,8aSR )‐8‐(pyrrolidin‐1‐yl)‐3,4,4a,5,6,7,8,8a‐octahydroquinolin‐1(2H )‐yl]ethan‐1‐one ((±)‐4 ) was prepared in a diastereoselective synthesis. The first key step of the synthesis was… Continue reading Enantiomerically Pure Quinoline-Based k-Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

Leah Pandiscia, PhD

Synthesis and Docking Study of N-(Cinnamoyl)-N′-(Substituted)acryloyl Hydrazide Derivatives Containing Pyridinium Moieties as a Novel Class of FtsZ Inhibitors against the Intractable Xanthomonas oryzae pv. oryzae Infections in Rice

2020 / Journal of Agriculture and Food Chemistry

Xanthomonas oryzae pv. oryzae (Xoo) is an offensive phytopathogen that can invade a wide range of plant hosts to develop… Continue reading Synthesis and Docking Study of N-(Cinnamoyl)-N′-(Substituted)acryloyl Hydrazide Derivatives Containing Pyridinium Moieties as a Novel Class of FtsZ Inhibitors against the Intractable Xanthomonas oryzae pv. oryzae Infections in Rice

Leah Pandiscia, PhD

Role of Side-Chain and Chirality of the Amino acids on the Supramolecular Assemblies of Dipeptides

2020 / Journal of Molecular Structure

The supramolecular self-association of alternating L/L and L/D amino acid-containing dipeptides, Boc-L-Ile-L-Phe-OMe (1), Boc-L-Ile-D-Phe-OMe (2), Boc-L-Ile-L-Phg-OMe (3, Phg = phenylglycine), and Boc-L-Ile-D-Phg-OMe… Continue reading Role of Side-Chain and Chirality of the Amino acids on the Supramolecular Assemblies of Dipeptides

Leah Pandiscia, PhD

Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites

2020 / Scientific Reports

Lipopolysaccharide (LPS) is a critical component of the outer membrane (OM) of many Gram-negative bacteria. LPS is translocated to the… Continue reading Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites

Leah Pandiscia, PhD

Homochiral Helical Coordination Architectures Built from Biphenyl-Based Amino Acid Derivatives: Structural Diversity Tuned by Varying Conformation and Configuration of N-donor ligands, Sensing of Acidic Amino Acids and Photoluminescence Properties

2020 / Crystal Growth & Design

Self-assembly of divalent metal ions and designed amino acid derivatives, 4,4′-biphenyl-bis[carbonyl-N-(alanine)] (H2BPBAla) and 4,4′-biphenyl-bis[carbonyl-N-(proline)] (H2BPBPro), as well as ancillary ligands,… Continue reading Homochiral Helical Coordination Architectures Built from Biphenyl-Based Amino Acid Derivatives: Structural Diversity Tuned by Varying Conformation and Configuration of N-donor ligands, Sensing of Acidic Amino Acids and Photoluminescence Properties

Leah Pandiscia, PhD

Comparison and optimization of extraction methods of extracellular polymeric substances in anammox granules: From maintaining protein secondary structure perspective

2020 / Chemosphere

Extracellular proteins are crucial for the formation and structural maintenance of anammox granules. However, the influence of extracellular polymeric substances… Continue reading Comparison and optimization of extraction methods of extracellular polymeric substances in anammox granules: From maintaining protein secondary structure perspective

Leah Pandiscia, PhD