Found 9617 Results / Page 419 of 481
2005 / FEBS Letters
Since it was implicated in a number of neurodegenerative conditions, such as Alzheimer disease, formation of β-sheet-rich protein fibrils (amyloids)… Continue reading Chiral bias of amyloid fibrils revealed by the twisted conformation of Thioflavin T: An induced circular dichroism/DFT study
2010 / Cancer Research
Nanotechnology offers novel delivery vehicles for cancer therapeutics. Potential advantages of nanoscale platforms include improved pharmacokinetics, encapsulation of cytotoxic agents,… Continue reading Induction of Cancer Cell Death by Self-assembling Nanostructures Incorporating a Cytotoxic Peptide
2016 / Chemistry A European Journal
The absolute stereostructures of trangmolins A–F (1–6), limonoids with three new and one known topologies of the rings A and… Continue reading Trangmolins A–F with an Unprecedented Structural Plasticity of the Rings A and B: New Insight into Limonoid Biosynthesis
2016 / Chemical and Pharmaceutical Bulletin
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an… Continue reading Sesquiterpenoids from the Rhizomes of Curcuma phaeocaulis and Their Inhibitory Effects on LPS-Induced TLR4 Activation
2016 / Chemical and Pharmaceutical Bulletin
New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The… Continue reading Hyrtinadines C and D, New Azepinoindole-Type Alkaloids from a Marine Sponge Hyrtios sp.
2016 / Biochemistry
Type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in the… Continue reading Construction of Functional Monomeric Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase
2016 / Organic & Biomolecular Chemistry
β-Annulus peptides bearing Cys at the N-terminal from tomato bushy stunt virus were synthesised using a standard Fmoc-protected solid-phase method,… Continue reading Self-assembly of Ni-NTA-modified β-annulus peptides into artificial viral capsids and encapsulation of His-tagged proteins
2016 / FEBS Letters
Human serum albumin (HSA) is an important protein involved in the transport of hormones, fatty acids, drugs and other macromolecules. Under… Continue reading Vitamin D prevents glycation of proteins: An In Vitro Study
2016 / Molecular Nutrition & Food Research
Pru p 1, the Bet v 1 homologue from peach, has been identified as a clinically relevant allergen. Three isoforms… Continue reading IgE-binding potencies of three peach Pru p 1 isoforms
2016 / Scientific Reports
Amyloid β-protein (Aβ42) oligomerization is an early event in Alzheimer’s disease (AD). Current diagnostic methods using sequence-specific antibodies against less… Continue reading Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis
2016 / Food Chemistry
Recently, high-intensity pulsed electric field (PEF) has successfully used in improvement of antioxidant activity. Ser-His-Cys-Met-Asn (SHCMN) obtained from soybean protein… Continue reading Effect of pulsed electric field (PEF) on structures and antioxidant activity of soybean source peptides-SHCMN
2016 / Scientific Reports
Conglutins represent the major peanut allergens and are renowned for their resistance to gastro-intestinal digestion. Our aim was to characterize… Continue reading Conformational stability of digestion-resistant peptides of peanut conglutins reveals the molecular basis of their allergenicity
2016 / Chemical and Pharmaceutical Bulletin
The homologous proteins MDM2 and MDMX negatively regulate the tumor suppressor protein p53 by antagonizing p53 transactivation activity and targeting… Continue reading Functional Interrogation of the N-Terminal Lid of MDMX in p53 Binding via Native Chemical Ligation
2016 / Chemistry and Biodiversity
Four new (1−4) and thirteen known (5−17) compounds were isolated from a rare cliff plant, Oresitrophe rupifraga. Based on spectroscopic evidence,… Continue reading Chemical Constituents of the Rare Cliff Plant Oresitrophe rupifraga and Their Anti-neuroinflammatory Activity
2016 / Chemical and Pharmaceutical Bulletin
Eleven 2′-N-acyl derivatives (5a–k) were prepared from ecteinascidin 770 (Et 770: 1b) viaknown 18,6′-O-bisallyl-protected compound (3) in three steps. Their in vitro cytotoxicities were… Continue reading Chemistry of Ecteinascidins. Part 5: An Additional Proof of Cytotoxicity Evaluation of Ecteinascidin 770 Derivatives
2016 / The Journal of Physical Chemistry C
Making the “DNA-metal base pairs” is one of the promising avenues for designing DNA based optical sensors and other potential… Continue reading Making and Breaking of DNA-Metal Base Pairs: Hg2+ and Au Nanocluster Based Off/On Probe
2016 / Inorganics
We have here synthesized new chiral Schiff base Ni(II), Cu(II), Zn(II) complexes (Ni, Cu, Zn) and hybrid materials with azobenzene (AZ) in… Continue reading The Viscosity and Intermolecular Interaction of Organic and Inorganic Hybrid Systems Composed of Chiral Schiff Base Ni(II), Cu(II), and Zn(II) Complexes with Long Ligands, Azobenzene, and PMMA
2016 / Biochemical Journal
Ezrin is member of the ERM (Ezrin-Radixin-Moesin) family of proteins that have been conserved through metazoan evolution. These proteins have… Continue reading Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin
2016 / Chinese Chemical Letters
Gastrolatathioneine (1), an unusual natural product derived from ergothioneine, a fungal amino acid containing an imidazole-2-thione moiety, was isolated from… Continue reading Gastrolatathioneine, an unusual ergothioneine derivative from an aqueous extract of “Tian ma”: A natural product co-produced by plant and symbiotic fungus
2016 / Polymer Chemistry
Melt polycondensation approach is developed for new classes of reduction responsive disulfide containing functional polyesters based on l-cystine amino acid resources… Continue reading Melt polycondensation approach for reduction degradable helical polyester based on l-cystine
