The fine control of enzyme activity is essential for the regulation of many important cellular and organismal functions. The light-regulation… Continue reading Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity
Leah Pandiscia, PhD
July 28, 2017
Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3 − and proton. CAV is… Continue reading Cloning, expression, purification and characterization of human mitochondrial carbonic anhydrase VA
Leah Pandiscia, PhD
July 28, 2017
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. The pathology of PD is caused by progressive degeneration of… Continue reading FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70
Leah Pandiscia, PhD
July 28, 2017
The aim of this present work is to investigate the interaction between doxorubicin and bovine serum albumin (BSA) in simulated… Continue reading Toxic Effects of Anticancer Drug Doxorubicin to Bovine Serum Albumin Evaluated by Spectroscopic Methods
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Eight structurally diverse cassane diterpenes named tomocins A–H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were… Continue reading Cassane diterpenes from the seed kernels of Caesalpinia sappan
Leah Pandiscia, PhD
July 28, 2017
The self-assembly behavior of a nonionic surfactant (n-dodecyl tetraethylene monoether, C12E4) and a peptide amphiphile (PA, C16-GK-3) mixed system was… Continue reading Modulating hierarchical self-assembly behavior of a peptide amphiphile/nonionic surfactant mixed system
Leah Pandiscia, PhD
July 28, 2017
Chitinase from T. kodakarensis (TkChiA) catalyzes the hydrolysis of chitin. The enzyme consists of two catalytic and three binding domains (ChBD1, ChBD2 and… Continue reading Crystal structures of chitin binding domains of chitinase from Thermococcus kodakarensis KOD1
Leah Pandiscia, PhD
July 28, 2017
I report surface modification of up-converting, Er3+ and Yb3+ co-doped β-NaYF4 nanoparticles with four types of chiral molecules with proven molecular chiral recognition… Continue reading Surface functionalization of up-converting NaYF4 nanocrystals with chiral molecules
Leah Pandiscia, PhD
July 28, 2017
A signal-on aptasensor was fabricated for highly sensitive and selective electrochemical detection of arsenite with a label-free Ars-3 aptamer self-assembled… Continue reading Label-free signal-on aptasensor for sensitive electrochemical detection of arsenite
Leah Pandiscia, PhD
July 28, 2017
Fluorescent proteins (FPs) engineered from bacterial phytochromes attract attention as probes for in vivo imaging due to their near-infrared (NIR) spectra and… Continue reading Allosteric effects of chromophore interaction with dimeric near-infrared fluorescent proteins engineered from bacterial phytochromes
Leah Pandiscia, PhD
July 28, 2017
Copolymerizations of substituted acetylenes have been intensively studied in solution polymerization for constructing chirally helical polymers, while emulsion copolymerizations of… Continue reading Emulsion copolymerization of substituted acetylenes for constructing optically active helical polymer nanoparticles. Synergistic effects and helicity inversion.
Leah Pandiscia, PhD
July 28, 2017
Phytocystatins belong to the family of cysteine proteinases inhibitors. They are ubiquitously found in plants and carry out various significant… Continue reading Purification and biochemical characterization of phytocystatin from Brassica alba
Leah Pandiscia, PhD
July 28, 2017
The absorption and circular dichroism (CD) spectra of three types of cyanine dyes with different lengths of methine group (3,3′-diethylthiadicarbocyanine… Continue reading Specific excitonic interactions in the aggregates of hyaluronic acid and cyanine dyes with different lengths of methine group
Leah Pandiscia, PhD
July 28, 2017
· Centrin binds to Rad4(XPC) and Sfi1 through the hydrophobic motif W1xxL4xxxL8 in the opposite orientation. Rad4 has one motif, but… Continue reading New insights into the interaction of centrin with Sfi1
Leah Pandiscia, PhD
July 28, 2017
Ferritins and bacterioferritins (Bfrs) utilize a binuclear non-heme iron binding site to catalyze oxidation of Fe(II), leading to formation of… Continue reading CD/MCD/VTVH-MCD Studies of Escherichia coli Bacterioferritin Support a Binuclear Iron Cofactor Site
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Amyloid β-protein (Aβ) sequence length variants with varying aggregation propensity coexist in vivo, where coaggregation and cross-catalysis phenomena may affect… Continue reading N‑Terminal Extensions Retard Aβ42 Fibril Formation but Allow CrossSeeding and Coaggregation with Aβ42
Leah Pandiscia, PhD
July 28, 2017
Amyloid protein fibrillation is associated with a variety of neurodegenerative and other diseases, and their efficient detection and monitoring can… Continue reading Detection and Monitoring of Amyloid Fibrillation Using a Fluorescence “Switch-On” Probe
Leah Pandiscia, PhD
July 28, 2017