2021 / Communications Biology
Circular tandem repeat proteins (‘cTRPs’) are de novo designed protein scaffolds (in this and prior studies, based on antiparallel two-helix… Continue reading Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces
2021 / Nature Communications
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated… Continue reading A protein tertiary structure mimetic modulator of the Hippo signalling pathway
2021 / Journal of Fungi
Monascus species are asexually or sexually reproduced homothallic fungi that can produce a red colorant, specifically the so-called red yeast… Continue reading Investigations into Chemical Components from Monascus purpureus with Photoprotective and Anti-Melanogenic Activities
2021 / Chromatography Today
Cannabinoid is a generic term for the chemical substances contained in cannabis plants. Tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD)… Continue reading Analysis of Cannabidiol in CBD products by SFC-CD-MS
2021 / Biophysical Journal
Understanding the structure of messenger RNA (mRNA) lipid nanoparticles, and specifically the microenvironment of the mRNA molecules within these entities,… Continue reading Encapsulation state of messenger RNA inside lipid nanoparticles
2021 / Scientific reports
5-Amino-8-hydroxyquinoline (5A8HQ), an amino derivative of 8-hydroxyquinoline, has become a potential anticancer candidate because of its promising proteasome inhibitory activity… Continue reading In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent
2021 / Scientific reports
The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies… Continue reading Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies
2021 / Scientific reports
Multidrug-resistant (MDR) Salmonella is a threat to public health. Non-antibiotic therapies could serve as important countermeasures to control MDR Salmonella… Continue reading Bovine NK-lysin peptides exert potent antimicrobial activity against multidrug-resistant Salmonella outbreak isolates
2021 / Bioorganic Chemistry
Nine undescribed monoterpene phenol dimers, bisbakuchiols D-L (1–9), were isolated from the fruits of Psoralea corylifolia L. Their structures were… Continue reading Bioactive monoterpene phenol dimers from the fruits of Psoralea corylifolia L.
2021 / Molecular Science
The bluish-purple petals of Chinese bellflower, Platycodon grandiflorum (kikyo in Japanese), contain platyconin (1) as the major anthocyanin. Platyconin (1)… Continue reading Polyacylated Anthocyanins in Bluish-Purple Petals of Chinese Bellflower, Platycodon grandiflorum
2021 / Soft Matter
Alkyl-substituted L/D-glutamide derivatives (L/D-SG) were designed as gelators to fabricate host gel matrices. Pyrene-appended L/D-glutamide derivatives (Py-LG/Py-DG) were employed as… Continue reading Inversing supramolecular chirality and boosting circularly polarized luminescence of pyrene moieties via a gel matrix
2021 / Nature Communications
Excessive replication of Saccharomyces cerevisiae Ty1 retrotransposons is regulated by Copy Number Control, a process requiring the p22/p18 protein produced… Continue reading Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control
2021 / Scientific Reports
In the emerging era of antimicrobial resistance, the susceptibility to co-infections of patients suffering from either acquired or inherited hemolytic… Continue reading Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity
2021 / Nature Communications
Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold… Continue reading Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
2021 / Scientific Reports
β-Propeller proteins are common natural disc-like pseudo-symmetric proteins that contain multiple repeats (‘blades’) each consisting of a 4-stranded anti-parallel β-sheet.… Continue reading Structure and stability of the designer protein WRAP-T and its permutants
2021 / Fitoterapia
Vernoramyosides A-F (1–6), six new Δ7,9(11) stigmastane-type steroid saponins, along with four known analogues (7–10) were isolated from the leaves… Continue reading Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del
2021 / frontiers in Microbiology
The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies… Continue reading Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
2021 / Communications Biology
Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a… Continue reading Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
2021 / Nucleic Acids Research
I-motif or C4 is a four-stranded DNA structure with a protonated cytosine:cytosine base pair (C+:C) found in cytosine-rich sequences. We… Continue reading AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation
2021 / Natural Product Research
Cladosporine A (1), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01.… Continue reading Cladosporine A, a new indole diterpenoid alkaloid with antimicrobial activities from Cladosporium sp.
