Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential

2016 / Food and Function

Glucitol-core containing gallotannins (GCGs) are polyphenols containing galloyl groups attached to a 1,5-anhydro-D-glucitol core, which is uncommon among naturally occurring… Continue reading Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential

Leah Pandiscia, PhD

Three New Chalcones from the Aerial Parts of Angelica keiskei

2016 / Helvetica Chimica Acta

Three new chalcones, 3′-carboxymethyl-4,2′-dihydroxy-4′-methoxychalcone (1), (±)-4,2′,4′-trihydroxy-3′-[(3-hydroxy-2,2-dimethyl-6-methylenecyclohexyl)methyl]chalcone (2), and 2′′-hydroxyangelichalcone (3), were isolated from the aerial parts of Angelica keiskei(Umbelliferae) together with… Continue reading Three New Chalcones from the Aerial Parts of Angelica keiskei

Leah Pandiscia, PhD

A Comparative Spectroscopic and Calorimetric Investigation of the Interaction of Amsacrine with Heme Proteins, Hemoglobin and Myoglobin

2016 / Journal of Biomolecular Structure and Dynamics

The binding of the anilido aminoacridine derivative amsacrine with the heme proteins, hemoglobin, and myoglobin, was characterized by various spectroscopic… Continue reading A Comparative Spectroscopic and Calorimetric Investigation of the Interaction of Amsacrine with Heme Proteins, Hemoglobin and Myoglobin

Leah Pandiscia, PhD

Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity

2016 / Scientific Reports

Flagellin has the capacity to activate both Toll-like receptor 5 (TLR5) and Nod-like receptor C4 (NLRC4)/neuronal apoptosis inhibitory protein 5… Continue reading Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity

Leah Pandiscia, PhD

Critical processing parameters of carbon dioxide spray drying for the production of dried protein formulations: A study with myoglobin

2016 / European Journal of Pharmaceutics and Biopharmaceutics

The aim of this study was to gain fundamental insight into protein destabilization induced by supercritical CO2 spray drying processing parameters.… Continue reading Critical processing parameters of carbon dioxide spray drying for the production of dried protein formulations: A study with myoglobin

Leah Pandiscia, PhD

Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun

2016 / Fitoterapia

Six new cyanoglucosides, 2S-cardiospermin-5-benzoate (1), 2R-cardiospermin-5-p-hydroxybenzoate (2), 2S-cardiospermin-5-cis-p-coumarate (3), isocardiospermin-5-p-hydroxybenzoate (4), sutherlandin-5-p-hydroxybenzoate (5), and sutherlandin-5-cis-p-coumarate (6), together with 17 known… Continue reading Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun

Leah Pandiscia, PhD

Analytical and semipreparative high performance liquid chromatography enantioseparation of bicalutamide and its chiral impurities on an immobilized polysaccharide-based chiral stationary phase

2016 / Journal of Chromatography A

Direct HPLC separation of enantiomers of Bicalutamide (BCT), a non-steroidal antiandrogen used for the treatment of prostate cancer, was performed… Continue reading Analytical and semipreparative high performance liquid chromatography enantioseparation of bicalutamide and its chiral impurities on an immobilized polysaccharide-based chiral stationary phase

Leah Pandiscia, PhD